Author

Javier F. Chaparro‐Riggers

Pfizer (United States)ORCID 0000-0002-5403-966XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Laura LiniD· 3 shared Alicia SolórzanoiD· 1 shared Azadeh PaksaiD· 1 shared Ching-Shin HuangiD· 1 shared Chong WangiD· 1 shared Christopher S. Lepsy· 1 shared Cindy Huynh· 1 shared Congsheng Cheng· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

Laura LinORCID

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Author profile →

3 papers

Recent·Most cited

Structural elucidation of the haptoglobin-hemoglobin clearance mechanism by macrophage scavenger receptor CD163

Ching-Shin Huang, Hui Wang, Joshua B. R. White, Oksana Degtjarik, Cindy Huynh, Kristoffer Brännström, Mark T. Horn, Stephen P. Muench, William S. Somers, Javier F. Chaparro‐Riggers, Laura Lin, Lidia Mosyak

This study determines the cryo-EM structures of CD163 in complex with haptoglobin-hemoglobin, revealing its trimeric structure and calcium-dependent mechanism for HpHb clearance.

PLoS Biology · Jul 11, 2025Peer-reviewedBiophysics

Self-amplifying mRNA expression is governed by mitochondrial machinery and ACSL4

Lara F. Tshering, Chong Wang, Qing Xiang, Sharmistha Kundu, Alicia Solórzano, Javier F. Chaparro‐Riggers, Laura Lin, Azadeh Paksa

The paper identifies mitochondrial function and ACSL4 as key regulators of self-amplifying mRNA (saRNA) expression, showing that modulating ACSL4 improves saRNA expression across cell types.

bioRxiv · Jun 13, 2025 · PreprintMolecular Biology

Increased FAN1 expression by mRNA-LNP attenuates CAG repeat expansion in Huntington patients' iPSC-derived astrocytes

Yung‐Chih Cheng, Gosia Nocula-Lugowska, Julita A Ramirez, Xiaoyu Fan, Fang Jin, Zhihua Jiang, Eric M. Bennett, Jin Li, David E. Hokanson, Sneha Grandhi, Michelle Chen, Congsheng Cheng, Guan-Yu Lin, Laura Lin, Christopher S. Lepsy, , Shian-Huey Chiang

The paper shows that increasing FAN1 expression in HD patient astrocytes reduces CAG repeat expansion using mRNA-LNP.

bioRxiv · Nov 24, 2023 · PreprintNeuroscience