TPR Domains Drive the Functional Phase Separation of HOP and its Regulation by Hsp90 and Hsp70
Benjamin S. Rutledge, Bryce E. Gnidec, Marko Vukčević, Solomon K. Hussein, Desmond Prah Amoah, Paul LaPointe, Marco A. M. Prado, Wing‐Yiu Choy, Martin L. Duennwald
This study shows HOP forms stress-induced biomolecular condensates via phase separation driven by TPR domains, regulated by Hsp70 and Hsp90, and its dysfunction increases misfolding stress.
bioRxiv · Jun 7, 2026 · PreprintBiochemistry