Author

Wing‐Yiu Choy

Western UniversityORCID 0000-0002-2124-7278Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Benjamin S. RutledgeiD· 2 shared Carter J. WilsoniD· 2 shared Marco A. M. PradoiD· 2 shared Martin L. DuennwaldiD· 2 shared Mikko KarttuneniD· 2 shared Bryce E. Gnidec· 1 shared Desmond Prah Amoah· 1 shared Edward A. FoniD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Benjamin S. RutledgeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TPR Domains Drive the Functional Phase Separation of HOP and its Regulation by Hsp90 and Hsp70

Benjamin S. Rutledge, Bryce E. Gnidec, Marko Vukčević, Solomon K. Hussein, Desmond Prah Amoah, Paul LaPointe, Marco A. M. Prado, Wing‐Yiu Choy, Martin L. Duennwald

This study shows HOP forms stress-induced biomolecular condensates via phase separation driven by TPR domains, regulated by Hsp70 and Hsp90, and its dysfunction increases misfolding stress.

bioRxiv · Jun 7, 2026 · PreprintBiochemistry

STIP1/HOP Promotes the Formation of Cytotoxic α-Synuclein Oligomers

Benjamin S. Rutledge, Carter J. Wilson, Rachel M. Lau, Juan Camilo Jurado-Coronel, Esther del Cid‐Pellitero, Mikko Karttunen, Thomas M. Durcan, Edward A. Fon, Marco A. M. Prado, Justin A. Legleiter, Martin L. Duennwald, Wing‐Yiu Choy

This study identifies how STIP1/HOP interacts with a-Syn to promote toxic oligomer formation in synucleinopathies.

Molecular Neurodegeneration Advances · Apr 24, 2026Peer-reviewedBiochemistry

AlphaFold2: A role for disordered protein prediction?

Carter J. Wilson, Wing‐Yiu Choy, Mikko Karttunen

This study evaluates AlphaFold2's ability to predict disordered protein regions compared to traditional predictors, finding pLDDT provides a better metric than DSSP.

International Journal of Molecular Sciences · Apr 21, 2022Peer-reviewedBioinformatics