Author

Paul LaPointe

University of AlbertaORCID 0000-0002-5465-1795Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

Desmond Prah Amoah· 2 shared Benjamin S. RutledgeiD· 1 shared Bryce E. Gnidec· 1 shared Gnin Alyousef· 1 shared Jill L. JohnsoniD· 1 shared Marco A. M. PradoiD· 1 shared Marko Vukčević· 1 shared Martin L. DuennwaldiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Desmond Prah Amoah

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJun 7, 2026

TPR Domains Drive the Functional Phase Separation of HOP and its Regulation by Hsp90 and Hsp70

Benjamin S. Rutledge, Bryce E. Gnidec, Marko Vukčević…·Martin L. Duennwald

This study shows HOP forms stress-induced biomolecular condensates via phase separation driven by TPR domains, regulated by Hsp70 and Hsp90, and its dysfunction increases misfolding stress.

DOI 10.64898/2026.06.05.730378

proteomicsbiophysical modeling

𝕏 PostBluesky

BiochemistryProtein SciencePeer-reviewedOct 22, 2025

Collaboration between two conserved sequence motifs drives ATPase stimulation of Hsp90 by Aha1

Desmond Prah Amoah, Rebecca Mercier, Gnin Alyousef…·Paul LaPointe

This study shows how two conserved motifs in Aha1 regulate Hsp90 ATPase activity and client protein folding by interacting structurally and functionally.

1 citation

yeastexperimental assay

𝕏 PostBluesky