Mitochondrial genome instability disrupts brown adipose tissue through pseudohypoxia-iron-NAD⁺ axis
Serena S Ozturk, Swagat Pradhan, Madeleine H. Lackman, Lipsa Rani Panda, Aleksandra Zhaivoron, Markus Innilä, João S. Patrício, Lauren G. Zacharias, Thomas P. Mathews, Sinem Karaman, Nahid Akthar Khan
This study identifies a pseudohypoxia-iron-NAD+ axis as a key driver of brown adipose tissue dysfunction in mitochondrial disease using a mouse model.
bioRxiv · Aug 31, 2026 · PreprintMolecular Biology