Nahid Akthar Khan

GDF15 modifies NAD+ salvage pathway and dampens immune response in mitochondrial disease

This study shows GDF15 enhances NAD+ salvage and reduces immune response in mitochondrial disease by upregulating NMRK2 and modulating redox homeostasis.

Mitochondrial genome instability disrupts brown adipose tissue through pseudohypoxia-iron-NAD⁺ axis

This study identifies a pseudohypoxia-iron-NAD+ axis as a key driver of brown adipose tissue dysfunction in mitochondrial disease using a mouse model.

NAD+ precursor treatment prevents cardiomyopathybut disrupts erythroid maturation in mitochondrial progeria

This study shows that NAD+ precursor treatment improves cardiac function but worsens erythroid maturation in mitochondrial progeria, highlighting tissue-specific effects of NAD+ boosting.

Nutrient-dependent pathology in mitochondrial hypertrophic cardiomyopathy model

This study examines how nutrient environments affect MRPL44-deficient cardiomyocytes, revealing distinct metabolic responses in glucose vs. lipid-rich conditions that contribute to mitochondrial hypertrophic cardiomyopathy.