Lauren G. Zacharias

This study uses metabolomics to analyze 474 subjects with inborn errors of metabolism, identifying genotype-specific metabolic alterations and providing diagnostic tools and a database of metabolomic features.

The paper investigates DAF-12 receptor ligand responsiveness in plant-parasitic nematodes and finds structural diversity in ligand recognition.

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

This study identifies a pseudohypoxia-iron-NAD+ axis as a key driver of brown adipose tissue dysfunction in mitochondrial disease using a mouse model.

This study identifies metabolic partnerships between medulloblastoma and macrophages that drive leptomeningeal metastases and suggests targeting the CXCL12-SCARB1-cholesterol axis as a therapeutic strategy.

This paper develops a covalent PFKL activator that disrupts cancer cell metabolism and delivers a cytotoxic payload, showing efficacy in vitro and in vivo.

This study shows that Nocturnin regulates mitochondrial NADP(H)/NAD(H) rhythms, affecting steroid rhythm amplitude and hepatic metabolism in mice.

The paper develops a biosensor to monitor α-ketoglutarate in human cells and identifies a mitochondrial-to-nuclear pathway regulating chromatin methylation.

The paper develops a platform to trace 30 nitrogen isotope-labeled metabolites, revealing cell state-specific pyrimidine synthesis pathway preferences in primitive and differentiated cells.

This study shows that L-2HG accumulation due to L2HGDH deficiency impairs neuronal differentiation by epigenetically activating MYC, leading to stem cell self-renewal and reduced neuron formation.

The paper characterizes the metabolomes of microglia, astrocytes, and neurons in aging and Alzheimer's brains, identifying cell-type-specific metabolic pathways and their changes with age and disease.

This study identifies NUDT5 as a regulator of purine metabolism and thiopurine sensitivity by interacting with PPAT, independent of its known enzymatic activity.

This study shows that disrupting autophagy in CAR-T cells enhances their metabolic activity and improves their ability to reject ovarian tumors in vivo.

This study shows mutant IDH reprograms neural progenitor cell fate by silencing Gsx2, promoting gliomagenesis through lineage switching.

This paper shows that blocking lipid synthesis in Drosophila fat body triggers a metabolic switch to glycogen storage, mediated by SREBP and HATs, supporting development but reducing lifespan and fecundity.

The paper introduces a web application for exploring metabolomics data from plasma and fibroblasts of patients with inborn errors of metabolism, enabling analysis of metabolic deviations and relationships.

This study maps the mouse brain metabolome using targeted metabolomics, creating detailed maps of 79 metabolites at high resolution.