Thomas P. Mathews

Choline Kinase Alpha Inhibition is a Mutation Agnostic Therapeutic Vulnerability in Clonal Hematopoiesis

This study identifies CHKA/PAF metabolic dependency in clonal hematopoiesis across multiple mutations and shows its suppression reduces clonal expansion.

Glutathione Protects Hematopoietic Stem Cells from Proteotoxic Stress

This study shows that glutathione is essential for proteostasis in hematopoietic stem cells but not for ferroptosis prevention.

Leptin Receptor+ cells create a perisinusoidal niche for thrombopoiesis in the bone marrow by synthesizing CXCL14

The paper identifies LepR+ cells as a niche for thrombopoiesis by producing CXCL14, which regulates lipid metabolism and terminal differentiation in megakaryocytes.

MCT1 activity defines an aggressive metabolic phenotype and therapeutic target in non-small cell lung cancer

This study shows that MCT1-mediated lactate uptake sustains nucleotide homeostasis in NSCLC, and its inhibition enhances chemotherapy efficacy by exposing a metabolic vulnerability.

Conservation of Nuclear Receptor DAF-12 with Evidence for Ligand Diversification in Plant-Parasitic Nematodes

The paper investigates DAF-12 receptor ligand responsiveness in plant-parasitic nematodes and finds structural diversity in ligand recognition.

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

Mitochondrial genome instability disrupts brown adipose tissue through pseudohypoxia-iron-NAD⁺ axis

This study identifies a pseudohypoxia-iron-NAD+ axis as a key driver of brown adipose tissue dysfunction in mitochondrial disease using a mouse model.

A Covalent PFKL Activator Suppresses Tumor Growth

This paper develops a covalent PFKL activator that disrupts cancer cell metabolism and delivers a cytotoxic payload, showing efficacy in vitro and in vivo.

Nocturnin drives mitochondrial NADP(H)/NAD(H) rhythms to regulate steroid rhythm amplitude and time metabolism

This study shows that Nocturnin regulates mitochondrial NADP(H)/NAD(H) rhythms, affecting steroid rhythm amplitude and hepatic metabolism in mice.

A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin

The paper develops a biosensor to monitor α-ketoglutarate in human cells and identifies a mitochondrial-to-nuclear pathway regulating chromatin methylation.

Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

The paper develops a platform to trace 30 nitrogen isotope-labeled metabolites, revealing cell state-specific pyrimidine synthesis pathway preferences in primitive and differentiated cells.

MitoSAM-dependent lipoylation controls postnatal heart development via metabolic remodeling

This study shows that mitoSAM-dependent lipoylation is essential for postnatal heart development by enabling metabolic remodeling from glycolysis to oxidative phosphorylation.

L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression

This study shows that L-2HG accumulation due to L2HGDH deficiency impairs neuronal differentiation by epigenetically activating MYC, leading to stem cell self-renewal and reduced neuron formation.

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT

This study identifies NUDT5 as a regulator of purine metabolism and thiopurine sensitivity by interacting with PPAT, independent of its known enzymatic activity.

Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis

This study shows mutant IDH reprograms neural progenitor cell fate by silencing Gsx2, promoting gliomagenesis through lineage switching.

NAD+ Sensing by PARP7 Regulates the C/EBPβ-Dependent Transcription Program in Adipose Tissue In Vivo

This study identifies PARP7 as a key regulator of C/EBPβ-dependent adipogenesis and shows it senses nuclear NAD+ levels to control gene expression and lipid production in mammary glands.

Ascorbate depletion increases quiescence and self-renewal potential in hematopoietic stem cells and multipotent progenitors

SREBP governs a triglyceride:glycogen metabolic switch in Drosophila

This paper shows that blocking lipid synthesis in Drosophila fat body triggers a metabolic switch to glycogen storage, mediated by SREBP and HATs, supporting development but reducing lifespan and fecundity.