A mitochondrial tipping point couples early hyperexcitability to late-stage failure in patient-derived ALS motor neurons
Jovan Prerad, Thomas Vanwelden, Marit van Gorsel, Seppe Vansteenkiste, Karolien Pipeleers, Marlies Reusen, Ilse Bastiaens, Thomas Libotton, Katrien Princen, Floor Stam, Gerard Griffioen, Marc L. Fivaz
This study shows that early hyperexcitability in ALS patient-derived motor neurons drives mitochondrial hypermetabolism, which later leads to mitochondrial failure and neuron loss.
bioRxiv · Mar 27, 2026 · PreprintNeuroscience