NeurosciencebioRxivPreprint
A mitochondrial tipping point couples early hyperexcitability to late-stage failure in patient-derived ALS motor neurons
Jovan Prerad, Thomas Vanwelden, Marit van Gorsel…·Marc L. Fivaz
This study shows that early hyperexcitability in ALS patient-derived motor neurons drives mitochondrial hypermetabolism, which later leads to mitochondrial failure and neuron loss.
DOI 10.64898/2026.03.20.713134