NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype in a novel zebrafish model for Dravet Syndrome
Wout J. Weuring, Sakshi Singh, Linda Volkers, Martin B. Rook, Ruben van ‘t Slot, Marjolein Bosma, Marco C. Inserra, Irina Vetter, Nanda M. Verhoeven‐Duif, Kees P. J. Braun, Mirko Rivara, Bobby P.C. Koeleman
This study develops a zebrafish model for Dravet Syndrome and tests compounds that selectively target Nav1.1 or Nav1.6 channels, showing both reduce seizure-like behavior.
PLoS ONE · Mar 5, 2020Peer-reviewedGenetics