Irina Vetter

E-Selectin Orchestrates IL-1B-Dependent Neuroinflammation via NLRP3 in Vincristine-Induced Neuropathy

This study identifies E-selectin as a key driver of IL-1B-dependent neuroinflammation in vincristine-induced neuropathy and suggests targeting E-selectin as a therapeutic strategy.

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant-negative impact on CSF1R signaling.

This study investigates a kinase-dead Csf1r mutation in mice, showing it causes dominant-negative effects on CSF1R signaling and impacts macrophage development and brain microglia.

NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype in a novel zebrafish model for Dravet Syndrome

This study develops a zebrafish model for Dravet Syndrome and tests compounds that selectively target Nav1.1 or Nav1.6 channels, showing both reduce seizure-like behavior.