Nanda M. Verhoeven‐Duif

VPS41 loss triggers iron overload, oxidative stress, and mitochondrial fragmentation linked to ferroptosis

This study shows that VPS41 loss causes iron overload, oxidative stress, and mitochondrial fragmentation, leading to ferroptosis and neurodegeneration.

NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype in a novel zebrafish model for Dravet Syndrome

This study develops a zebrafish model for Dravet Syndrome and tests compounds that selectively target Nav1.1 or Nav1.6 channels, showing both reduce seizure-like behavior.

Pyridox(am)ine 5’-phosphate oxidase deficiency induces seizures in Drosophila melanogaster

This study establishes Drosophila models of PNPO deficiency, showing seizures and lethality linked to low PLP levels, and demonstrates functional conservation between human and fly PNPO.