Discovery and isolation of novel capsaicinoids and their TRPV1-related activity
Joshua David Smith, Vendula Tvrdoňová, Martin Dračínský, Martin Popr, Hannah Lovinda Angermeier Gaustad, Quentin Lorenzi, Helena Smrčková, Jakob Klaus Reinhardt, Marjorie A. Liénard, Lucie Bednářová, Pavel Šácha, Tomáš Pluskal
The paper identifies and isolates novel capsaicinoids from chilis, showing structural variations significantly impact TRPV1 activation and demonstrating non-pungent compounds modulate capsaicin's effects.
European Journal of Pharmacology · May 2, 2025Peer-reviewedPharmacology & Toxicology