Pavel Šácha

The paper identifies and isolates novel capsaicinoids from chilis, showing structural variations significantly impact TRPV1 activation and demonstrating non-pungent compounds modulate capsaicin's effects.

The paper develops a non-radioactive screening assay for insulin receptor ligands that is faster and more sensitive than existing radioligand assays.

The paper presents a qPCR-based method for high-throughput screening of FDA-approved compounds as FAP inhibitors and demonstrates its application in quantifying FAP in human plasma.

This paper develops polymer-tethered fluorescent probes for tumor-associated protease imaging, showing improved signal and tumor-to-background ratios compared to small molecule probes.