SBT-272 improves TDP-43 pathology in the ALS motor cortex by modulating mitochondrial integrity, motility, and function
Mukesh Gautam, Barış Genç, Benjamin Helmold, Angela Ahrens, Janis Kuka, Marina Makrecka‐Kuka, Aksu Günay, Nuran Koçak, Izaak R. Aguilar-Wickings, Dennis Keefe, Guozhu Zheng, Suchitra Swaminathan, Martin Redmon, Hatim A. Zariwala, P. Hande Özdi̇nler
This study shows that SBT-272 improves mitochondrial structure, motility, and function in TDP-43 pathology of ALS motor neurons, reducing inflammation and preserving neuron health.
bioRxiv · Oct 4, 2022 · PreprintNeuroscience