Author

Dennis Keefe

Stealth BioTherapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:rat· 1

Frequent Co-Authors

Aksu GünayiD· 1 shared Angela Ahrens· 1 shared Athanasios DidangelosiD· 1 shared Atsushi AsakuraiD· 1 shared Barış GençiD· 1 shared Benjamin HelmoldiD· 1 shared Ewa SzulaiD· 1 shared Guo‐Hua FongiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperNeuroscience

Aksu GünayORCID

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Author profile →

3 papers

Recent·Most cited

CTx001 for geographic atrophy: a gene therapy expressing soluble, truncated complement receptor 1 (mini-CR1)

Sonika Rathi, Athanasios Didangelos, Sofiya Pisarenka, Rachel Green, Stamatia Zafeiri, Peter G. Billcliff, Nakul Patel, Pamela Whalley, Parisa Zamiri, Viranga Tilakaratna, Ewa Szula, Rafiq Hasan, Mustafa M. Munye, Richard D. Unwin, Paul N. Bishop, , Simon J. Clark

This paper develops CTx001, a gene therapy expressing mini-CR1, which reduces MAC formation in a rat model of geographic atrophy.

Ophthalmology Science · Oct 22, 2025Peer-reviewedBiochemistry

SBT-272 improves TDP-43 pathology in the ALS motor cortex by modulating mitochondrial integrity, motility, and function

Mukesh Gautam, Barış Genç, Benjamin Helmold, Angela Ahrens, Janis Kuka, Marina Makrecka‐Kuka, Aksu Günay, Nuran Koçak, Izaak R. Aguilar-Wickings, Dennis Keefe, Guozhu Zheng, Suchitra Swaminathan, Martin Redmon, Hatim A. Zariwala, P. Hande Özdi̇nler

This study shows that SBT-272 improves mitochondrial structure, motility, and function in TDP-43 pathology of ALS motor neurons, reducing inflammation and preserving neuron health.

bioRxiv · Oct 4, 2022 · PreprintNeuroscience

Amelioration of muscular dystrophy phenotype in mdx mice by inhibition of Flt1

Mayank Verma, Yuko Shimizu‐Motohashi, Yoko Asakura, James P. Ennen, Jennifer Bosco, Zhiwei Zhou, Guo‐Hua Fong, Serene Josiah, Dennis Keefe, Atsushi Asakura

This study shows that inhibiting Flt1 improves the muscular dystrophy phenotype in mdx mice by increasing vascular density and reducing muscle pathology.

PLoS Genetics · Dec 26, 2019Peer-reviewedDevelopmental Biology