Establishment of a humanized patient-derived xenograft mouse model of high-grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Luka Tandarić, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars A. Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns
This study develops a humanized xenograft model of high-grade serous ovarian cancer to evaluate immunotherapy, finding no treatment response but identifying immune-excluded tumor phenotypes.
International Journal of Gynecological Cancer · Feb 1, 2026Peer-reviewedCancer Biology