Author

Mary C. Karom

Georgia State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:rat· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Anne Z. MurphyiD· 2 shared Evan F. FullertoniD· 2 shared John M. StreicheriD· 1 shared Larry J. YoungiD· 1 shared Myurajan RubaharaniD· 1 shared Richard I. Hanberry· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersNeuroscience

Anne Z. MurphyORCID

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2 papers

Recent·Most cited

Age-induced changes in Mu Opioid Receptor signaling in the midbrain Periaqueductal Gray of male and female rats

Evan F. Fullerton, Mary C. Karom, John M. Streicher, Larry J. Young, Anne Z. Murphy

This study examines age and sex differences in opioid receptor signaling in the vlPAG of rats, finding reduced receptor binding, G-protein activation, and cAMP inhibition in aged rats, along with increased RGS4 and RGS9-2 expression, which may explain reduced opioid potency in aging.

Journal of Neuroscience · Jul 5, 2022Peer-reviewedNeuroscience

Advanced age attenuates the antihyperalgesic effect of morphine and decreases μ-opioid receptor expression and binding in the rat midbrain Periaqueductal Gray in male and female rats

Evan F. Fullerton, Myurajan Rubaharan, Mary C. Karom, Richard I. Hanberry, Anne Z. Murphy

This study shows that aging reduces morphine's pain-relieving effect and lowers μ-opioid receptor levels in the rat midbrain PAG, affecting both males and females.

Neurobiology of Aging · Oct 27, 2020Peer-reviewedNeuroscience