Anne Z. Murphy

This study examines the effects of gestational opioid exposure on learning and memory in rats, finding spatial and associative learning impairments that can be mitigated by environmental enrichment in males.

This study examines the effects of perigestational morphine exposure on hippocampal development in rats, finding delayed neuronal maturation and altered BDNF expression, which can be mitigated by environmental enrichment.

This study shows that perinatal morphine exposure in rats causes long-term intestinal microbiota changes that may affect immune system development and increase infection risk.

This study examines the effects of perinatal morphine exposure on maternal behavior and offspring anhedonia in rats, finding disrupted maternal behavior and reduced sucrose preference in offspring.

This study shows that perinatal morphine exposure in rats increases fever and sickness behavior after LPS, suggesting impaired immune function and increased infection susceptibility.

This study shows early life pain in rats increases febrile response and alters brain region activity after an immune challenge in adulthood.

This study shows that perigestational opioid exposure in rats alters alcohol and sucrose reward behaviors, with sex-specific effects on consumption and receptor expression.

This study shows that perinatal morphine exposure reduces social play in adolescent female rats, possibly due to altered oxytocin signaling in the nucleus accumbens.

This study examines age and sex differences in opioid receptor signaling in the vlPAG of rats, finding reduced receptor binding, G-protein activation, and cAMP inhibition in aged rats, along with increased RGS4 and RGS9-2 expression, which may explain reduced opioid potency in aging.

The paper investigates changes in the PVN-to-CA2 oxytocin pathway in heart failure rats, finding altered oxytocinergic innervation and reduced OTR-expressing astrocytes.

This study shows that aging reduces morphine's pain-relieving effect and lowers μ-opioid receptor levels in the rat midbrain PAG, affecting both males and females.