John M. Streicher

Discovery and dynamic pharmacology of μ-opioid receptor positive allosteric modulators

This study discovers μ-opioid receptor positive allosteric modulators (PAMs) and investigates their dynamic mechanism of action to enhance opioid agonist activity while reducing side effects.

Inhibiting Spinal Cord-Specific Hsp90 Isoforms Reveals a Novel Strategy to Improve the Therapeutic Index of Opioid Treatment

This paper shows that inhibiting specific spinal cord Hsp90 isoforms enhances opioid pain relief while reducing tolerance and side effects.

The Role of Ryanodine Receptor 2 in Drug-Associated Learning

This study examines RyR2 expression and localization in the vmPFC during drug and sucrose self-administration and reward recall, finding that drug recall alters RyR2P distribution and increases its somatic expression.

Terpenes from Cannabis sativa Induce Antinociception in Mouse Chronic Neuropathic Pain via Activation of Spinal Cord Adenosine A2A Receptors

This study shows Cannabis terpenes reduce chronic neuropathic pain in mice by activating spinal cord adenosine A2A receptors, with efficacy comparable to morphine.

Age-induced changes in Mu Opioid Receptor signaling in the midbrain Periaqueductal Gray of male and female rats

This study examines age and sex differences in opioid receptor signaling in the vlPAG of rats, finding reduced receptor binding, G-protein activation, and cAMP inhibition in aged rats, along with increased RGS4 and RGS9-2 expression, which may explain reduced opioid potency in aging.

Targeting the CaV - interaction yields a selective antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy

The paper identifies a novel CaV2.2 channel antagonist with broad antinociceptive effects and reduced side effects in pain models.