Larry J. Young

The paper examines how social reward behaviors relate to dopamine release patterns in male and female mice, finding sex-dependent differences in phasic and tonic dopamine responses.

The paper identifies a critical stress exposure period that drives neurophysiological changes in CRF neurons, leading to resilience in mice exposed to repeated social defeat stress.

The paper shows that a SNP in the oxytocin receptor gene affects social observation behavior in female prairie voles, with C/C genotype females spending more time observing novel males.

This study shows that knocking down oxytocin receptors in specific brain regions of female mice reduces stress-induced social avoidance behaviors.

The paper shows that ventral hippocampal neurons in prairie voles encode pair-bonded partner identity nonlinearly through 3-4 Hz oscillations.

The paper shows that BLA neurons in mice encode social and food rewards distinctly, with differences in response bias and sensitivity to reward omissions compared to mPFC.

This study shows that pair bonding in male mandarin voles increases DA release and alters activity in NAc shell D1 and D2 MSNs, with D2 MSN inhibition enhancing pair bond formation.

This study shows prairie voles can recognize individual vocalizations of their mates, with acoustic variation across individuals allowing identification above chance.

This study links natural variation in oxytocin receptor signaling to changes in brain transcription, particularly in the natural killer gene complex, suggesting a mechanism for social behavior diversity.

The paper generates transgenic mice with prairie vole Oxtr locus to study how long-range genomic regulation affects brain OXT receptor expression and social behaviors.

This study shows BNSTovCRF neurons promote resilience by reducing the internal experience of aversion during stress.

This study examines age and sex differences in opioid receptor signaling in the vlPAG of rats, finding reduced receptor binding, G-protein activation, and cAMP inhibition in aged rats, along with increased RGS4 and RGS9-2 expression, which may explain reduced opioid potency in aging.

This study shows that social experience alters oxytocinergic signaling in the nucleus accumbens of female prairie voles, affecting synaptic transmission and social behavior.

The paper compares gene expression in brain regions of prairie voles and meadow voles to identify species differences associated with pair bonding.

This study generates PIGA-deficient mouse models to investigate the role of GPI anchor deficiency in neurological phenotypes and seizure susceptibility.

This study estimates heritability of social behavior and central oxytocin in rhesus macaques and tests SNP associations with behavior and oxytocin levels, finding no significant SNP effects.