Hypoxia-Sensing CAR T-Cells Provide Safety and Efficacy in Treating Solid Tumors
Paris Kosti, James W. Opzoomer, Karen I. Larios-Martinez, Rhonda Henley‐Smith, Cheryl L. Scudamore, Mary Okesola, Mustafa Yassin Taher, David Marc Davies, Tamara Muliaditan, Daniel Larcombe-Young, Natalie L. Woodman, Cheryl Gillett, Selvam Thavaraj, John F. Maher, James N. Arnold
This paper develops hypoxia-sensing CAR T-cells that selectively target solid tumors without off-tumor toxicity using murine xenograft models.
Cell Reports Medicine · Apr 1, 2021Peer-reviewedSynthetic Biology