Author

Paris Kosti

Centre Hospitalier Universitaire VaudoisORCID 0000-0002-8558-1064Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Synthetic Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Apostolos Sarivalasis· 1 shared Asia Andreoli· 1 shared Aspram MinasyaniD· 1 shared Bovannak Stewen ChapiD· 1 shared Chahin AchtariiD· 1 shared Cheryl GillettiD· 1 shared Cheryl L. ScudamoreiD· 1 shared Christine SempouxiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperSystems Biology

Apostolos Sarivalasis

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Actionable spatial prostanoid barriers constrain BiTE-driven adoptive T cell immunity in intact human tumors

Bovannak Stewen Chap, Tania Santoro, Paris Kosti, David Barras, Noémie Fahr, Mathieu Desbuisson, Fabrizio Benedetti, Aspram Minasyan, Asia Andreoli, E. Ghisoni, Flavia De Carlo, Khadidja Benkortbi, Apostolos Sarivalasis, Chahin Achtari, Delfyne Hastir, , Denarda Dangaj Laniti

The paper uses patient-derived explants to study BiTE-driven T cell responses in tumors, identifying the COX/PGE2 axis as a barrier to immune activation and showing COX inhibition enhances anti-tumor effects.

bioRxiv · Mar 30, 2026 · PreprintSystems Biology

Hypoxia-Sensing CAR T-Cells Provide Safety and Efficacy in Treating Solid Tumors

Paris Kosti, James W. Opzoomer, Karen I. Larios-Martinez, Rhonda Henley‐Smith, Cheryl L. Scudamore, Mary Okesola, Mustafa Yassin Taher, David Marc Davies, Tamara Muliaditan, Daniel Larcombe-Young, Natalie L. Woodman, Cheryl Gillett, Selvam Thavaraj, John F. Maher, James N. Arnold

This paper develops hypoxia-sensing CAR T-cells that selectively target solid tumors without off-tumor toxicity using murine xenograft models.

Cell Reports Medicine · Apr 1, 2021Peer-reviewedSynthetic Biology