Lipoprotein lipase requires a flexible lid and stable C-terminal, both maintained by ApoC-II peptide binding
Emma E Lietzke, Mary S. Rouse, Dean Oldham, Ziyue Dong, Robert H. Eckel, Kayla G. Sprenger, Kimberley D. Bruce
This study uses molecular dynamics simulations and biochemical assays to show that ApoC-II peptide binding stabilizes LPL's structure and regulates its activity through lid flexibility and CTD flipping.
bioRxiv · Nov 20, 2025 · PreprintMolecular Biology