Author

Robert H. Eckel

University of Colorado AnschutzORCID 0000-0002-4870-4600Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Kayla G. SprengeriD· 2 shared Kimberley D. BruceiD· 2 shared Athena SchepmoesiD· 1 shared Chinemerum P. Ogbu· 1 shared Christy S. NiemeyeriD· 1 shared Dean OldhamiD· 1 shared Emma E LietzkeiD· 1 shared Hannah M. Binfet· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Kayla G. SprengerORCID

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2 papers

Recent·Most cited

ApoE Lipidation State Directs Immunometabolic Reprogramming of Human Microglia

Tsion G. Shiferaw, Snigdha Sarkar, Katelyn M. Baker, Rowan S. Wooldridge, Hannah M. Binfet, Victoria N. Prozapas, Chinemerum P. Ogbu, Athena Schepmoes, Isaac Kwame Attah, Christy S. Niemeyer, Kayla G. Sprenger, James E. Hassell, Robert H. Eckel, John Melchior, Kimberley D. Bruce

This study shows that ApoE4 lipidation state affects human microglial metabolism and function, with lipid-bound ApoE4 causing metabolic reprogramming and lipid-free ApoE4 inducing inflammatory signaling.

bioRxiv · May 7, 2026 · PreprintNeuroscience

Lipoprotein lipase requires a flexible lid and stable C-terminal, both maintained by ApoC-II peptide binding

Emma E Lietzke, Mary S. Rouse, Dean Oldham, Ziyue Dong, Robert H. Eckel, Kayla G. Sprenger, Kimberley D. Bruce

This study uses molecular dynamics simulations and biochemical assays to show that ApoC-II peptide binding stabilizes LPL's structure and regulates its activity through lid flexibility and CTD flipping.

bioRxiv · Nov 20, 2025 · PreprintMolecular Biology