Dean Oldham

This study investigates how HSV-1 infection remodels microglial transcriptional and epigenetic states, revealing IFN-responsive dominance and loss of homeostatic signatures in specific brain regions.

This study uses molecular dynamics simulations and biochemical assays to show that ApoC-II peptide binding stabilizes LPL's structure and regulates its activity through lid flexibility and CTD flipping.

This study investigates age- and sex-related metabolic changes in female brains and microglia, finding that estrogen may suppress disease-associated microglia (DAM) factors, potentially increasing Alzheimer's disease risk in post-menopausal women.