Mashaal Sohail

Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples

This study shows natural selection reduces the accuracy of polygenic scores in predicting traits from ancient humans by altering genetic variation patterns.

The multi-scale complexity of human genetic variation beyond continental groups

The paper introduces a network-based method to analyze human genetic variation beyond continental groups, revealing complex relationships and challenging traditional clustering approaches.

Nationwide genomic biobank in Mexico unravels demographic history and complex trait architecture from 6,057 individuals

The genetic architecture of the human skeletal form

The paper uses deep learning on DXA images to identify genetic variants affecting skeletal proportions and links these to evolutionary changes and disease risk.