Author

Mathilde Morisseau

Institut universitaire du cancer de Toulouse Oncopole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Agnese CristiniiD· 1 shared Amélie LusqueiD· 1 shared Anne Casanova· 1 shared Anne PradinesiD· 1 shared Camille Taha· 1 shared Célia DelahayeiD· 1 shared Delphine PaganiD· 1 shared Elodie Borrull· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Agnese CristiniORCID

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1 paper

Recent·Most cited

Persistent TOP1 cleavage complexes in drug-tolerant cells drive adaptive resistance to EGFR-targeted therapies in lung cancer

Mathéa Géraud, Rémi Gence, Anne Casanova, Estelle Clermont, Simona Salimbeni, Nesibe Özsu, Maïna Vienne, Célia Delahaye, Elodie Borrull, Amélie Lusque, Mathilde Morisseau, Thomas Filleron, Delphine Pagan, Camille Taha, Agnese Cristini, , Olivier Sordet

The paper shows that persistent TOP1 cleavage complexes in drug-tolerant lung cancer cells drive adaptive resistance to EGFR-targeted therapies by promoting mutagenesis and reveals TDP1 loss as a targetable vulnerability.

Science Advances · Sep 23, 2026Peer-reviewedMolecular Biology