Deep mutational scan of the pore of the cold-sensing TRPM8 channel
Averi L. Pike, Vincent Le, Ashlin Turner, Carmen Galván, Ashley Vazhavilla, Richard Salinas, Matt Bramble, Dennis Wylie, Jessica W. Podnar, Ian Hoskins, Can Cenik, Andrés Jara-Oseguera
The paper uses deep mutational scanning to study the TRPM8 channel's pore region, revealing how structural elements coordinate gating and ion selectivity in response to menthol and cold.
bioRxiv · May 1, 2026 · PreprintBiophysics