Andrés Jara-Oseguera

The paper uses deep mutational scanning to study the TRPM8 channel's pore region, revealing how structural elements coordinate gating and ion selectivity in response to menthol and cold.

The paper identifies M308 in TRPV1's ARD as a functionally significant residue with implications for channel activity and splice variant expression.

This study engineers RTx sensitivity in TRPV3 by mutating residues corresponding to the TRPV1 vanilloid site and shows that activation requires additional factors like pore mutations or co-agonists.