Ian Hoskins

The paper uses deep mutational scanning to study the TRPM8 channel's pore region, revealing how structural elements coordinate gating and ion selectivity in response to menthol and cold.

The paper analyzes ribosome profiling data to show translation efficiency covariation (TEC) is conserved across human and mouse cells, revealing gene functions not evident from RNA or protein co-expression.

The paper integrates multiplexed assays to identify cis-regulatory variants affecting COMT gene expression across multiple layers.

This paper develops Ribo-ITP to measure ribosome occupancy in single cells during early mouse development, revealing differential translation efficiency and allele-specific ribosome engagement.

satmut_utils is a tool for simulating and analyzing saturation mutagenesis data, showing that single-codon variants can alter mRNA abundance and demonstrating improved variant calling performance.

The paper identifies genes with 5' terminal oligopyrimidine tracts that escape suppression by SARS-CoV-2 NSP1 through RNA-Seq and ribosome profiling, revealing a role for LARP1 in their preferential translation.