Screening of a chemogenetic library unveils dual-stage antimalarials with low cytotoxicity
Laura Torres, Matthew E. Fishbaugher, Melanie Lam, Alexander Theodore Chao, Calla Martyn, Luying Pei, Debapriya Sengupta, Maxime Dauphinais, Jonathan E. Gable, Srinivasa P. S. Rao, Steffen Renner, Armand Guiguemde, Sebastian A. Mikolajczak, Anke Harupa-Chung, Gabriel Mitchell
This study screens a chemogenetic library to identify antimalarial compounds with dual-stage activity against Plasmodium liver and blood stages, showing low cytotoxicity.
bioRxiv · Oct 26, 2025 · PreprintMicrobiology