PBAE-PEG based lipid nanoparticles for lung cell-specific gene delivery
Bingxin Liu, Yamato Sajiki, Nicole Littlefield, Yongxian Hu, William D. Stuart, Anusha Sridharan, Xuemei Cui, Matthew E. Siefert, Koichi Araki, Assem G. Ziady, Donglu Shi, Jeffery A Whitsett, Yutaka Maeda
This paper develops PBAE-PEG and PBAE lipid nanoparticles for targeted mRNA delivery to lung cells, showing differential efficacy in transfecting pulmonary endothelial and epithelial cells via different routes.
Molecular Therapy · Jan 25, 2025Peer-reviewedBioengineering