Author

Matthew E.C. Bourkas

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Erica StuartiD· 2 shared Hamza ArshadiD· 2 shared Joel C. WattsiD· 2 shared Surabhi MehraiD· 2 shared Surachai SupattaponeiD· 2 shared Daniel J. WalshiD· 1 shared Genki Amano· 1 shared Gerold Schmitt‐UlmsiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Erica StuartORCID

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2 papers

Recent·Most cited

PRNP mutations initially generate an alternatively misfolded PrP species that dissuades prion replication

Genki Amano, Hamza Arshad, Surabhi Mehra, Matthew E.C. Bourkas, Erica Stuart, Gerold Schmitt‐Ulms, Surachai Supattapone, Joel C. Watts

The paper identifies an alternatively misfolded PrP species, PrPAM, generated by PRNP mutations that may initially protect against prion replication, explaining delayed disease onset.

bioRxiv · Sep 28, 2026 · PreprintNeuroscience

Convergent generation of atypical prions in knock-in mouse models of genetic prion disease

Surabhi Mehra, Matthew E.C. Bourkas, Lech Kaczmarczyk, Erica Stuart, Hamza Arshad, Jennifer K. Griffin, Kathy L. Frost, Daniel J. Walsh, Surachai Supattapone, Stephanie A. Booth, Walker S. Jackson, Joel C. Watts

This study shows that knock-in mice with specific prion protein mutations spontaneously develop prion disease, producing atypical prion strains with similar properties regardless of mutation type.

bioRxiv · Sep 26, 2023 · PreprintNeuroscience