Walker S. Jackson

Central role for fast nociceptors in mechanical nocifensive behavior and sensitization

This study identifies fast-conducting mechano-nociceptors as essential for mechanical nocifensive behaviors and sensitization in mice and humans.

PrP turnover in vivo and the time to effect of prion disease therapeutics

The paper measures PrP half-life in vivo and shows it limits the time to effect of PrP-lowering therapies, with implications for drug development and clinical trial design.

Prion shedding is reduced by chronic wasting disease vaccination

This study shows that vaccination reduces prion shedding in feces and urine of CWD-infected mice, potentially breaking the transmission cycle.

A NaV1.8FlpO mouse enabling selective intersectional targeting of low threshold C fiber mechanoreceptors and nociceptors

The paper introduces a new mouse line expressing FlpO recombinase specifically in NaV1.8-expressing sensory neurons, enabling selective intersectional targeting of C-fiber mechanoreceptors and nociceptors.

Genetic targeting of myelinated primary afferent neurons using a new NefhCreERT2 knock-in mouse

This paper introduces a new NefhCreERT2 knock-in mouse line for selectively targeting myelinated primary afferent neurons, enabling genetic studies of these fibers while excluding unmyelinated C fibers.

Alternative splicing generates a Ribosomal Protein S24 isoform induced by neuroinflammation and neurodegeneration

The paper identifies Rps24c/S24-PKE as a novel marker for neuroinflammation and neurodegeneration through cell type-specific alternative splicing in mouse brains.

The Disc1 deletion common to many inbred mouse strains has negligible effects on social behavior of 129S4 mice in a semi-natural environment

This study investigates the impact of a natural Disc1 deletion in 129S4 mice on social behavior in a semi-natural environment, finding minimal effects.

A fast nociceptive subsystem mediating rapid reflexive behavior but not affective pain

The paper identifies a fast nociceptive pathway that mediates rapid reflexive behavior but not affective pain.

The Brain Interactome of a Permissive Prion Replication Substrate

The paper compares the interactomes of mouse and bank vole prion proteins in brain tissue to determine if differences in protein interactions explain the bank vole's susceptibility to prions.

DNA G-quadruplex is a transcriptional control device that regulates memory

The paper shows DNA G-quadruplex regulates gene expression in neurons, affecting memory formation and fear extinction.

Convergent generation of atypical prions in knock-in mouse models of genetic prion disease

This study shows that knock-in mice with specific prion protein mutations spontaneously develop prion disease, producing atypical prion strains with similar properties regardless of mutation type.

Therapeutic trial of anle138b in mouse models of genetic prion disease

This study tests anle138b in mouse models of prion disease, finding improved survival in RML strain models but no clear endpoints in genetic mutation models.

Cerebellar granule neurons induce Cyclin D1 in an early stage of Huntington's disease

The paper identifies cell type-specific transcriptomic changes in cerebellar neurons of a Huntington's disease mouse model, highlighting cyclin D1 upregulation in granule cells.

Simultaneous pathway engagement of translation in astrocytes, circadian rhythm in GABAergic neurons and cytoskeleton in glutamatergic neurons precede electroencephalographic changes in neurodegenerative prion disease

The paper identifies early translatome changes in specific neural cell types before EEG and neuropathological signs of prion disease in mice.

Insights into calcium signaling and gene expression in astrocytes uncovered with 129S4 Slc1a3-2A-CreERT2 knock-in mice

The paper compares behavioral traits between C57Bl/6 and 129S4 mice, establishes a new Cre mouse line for astrocyte study, and investigates calcium signaling and gene expression in astrocytes.

Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including Human

This study identifies CalDAG-GEFI mutations causing psychomotor symptoms and bleeding in multiple species, revealing conserved signaling deficits in striatal function.

Memory trace superimposition impairs recall in a mouse model of AD

The paper shows that in a mouse model of AD, memory recall is impaired due to the superimposition of new neurons onto the memory trace during retrieval.