Author

Genki Amano

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:protein structure prediction· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Gerold Schmitt‐UlmsiD· 3 shared Hamza ArshadiD· 3 shared Joel C. WattsiD· 3 shared Surabhi MehraiD· 2 shared Zeel PateliD· 2 shared Erica StuartiD· 1 shared Leyao Li· 1 shared Matthew E.C. Bourkas· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersNeuroscience

Gerold Schmitt‐UlmsORCID

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3 papers

Recent·Most cited

PRNP mutations initially generate an alternatively misfolded PrP species that dissuades prion replication

Genki Amano, Hamza Arshad, Surabhi Mehra, Matthew E.C. Bourkas, Erica Stuart, Gerold Schmitt‐Ulms, Surachai Supattapone, Joel C. Watts

The paper identifies an alternatively misfolded PrP species, PrPAM, generated by PRNP mutations that may initially protect against prion replication, explaining delayed disease onset.

bioRxiv · Sep 28, 2026 · PreprintNeuroscience

The Protein Disulfide Isomerase P4HB/PDIA1 Modulates PrPC Levels and Prion Replication

Genki Amano, Hamza Arshad, Zeel Patel, Gerold Schmitt‐Ulms, Joel C. Watts

This study shows that P4HB/PDIA1 modulates PrPC levels and prion replication by stabilizing PrPC and acting as a chaperone in CAD5 cells.

bioRxiv · Dec 3, 2025 · PreprintNeuroscience

The Molecular Determinants of a Universal Prion Acceptor

Hamza Arshad, Zeel Patel, Zaid A.M. Al‐Azzawi, Leyao Li, Genki Amano, Surabhi Mehra, Shehab Eid, Gerold Schmitt‐Ulms, Joel C. Watts

The paper identifies key amino acid residues in bank vole prion protein (BVPrP) that enable it to act as a universal prion acceptor, revealing molecular mechanisms for cross-species prion replication.

PLoS Pathogens · Sep 10, 2024Peer-reviewedNeuroscience