Loss of the Alzheimer’s-linked bridging integrator 1 (BIN1) protein affects synaptic structure and disrupts tau localisation and release
Elizabeth B. C. Glennon, Dawn H. W. Lau, Rebecca M. C. Gabriele, Matthew F Taylor, Claire Troakes, Sarah Opie-Martin, Christina Elliott, Richard Killick, Diane P. Hanger, Beatriz Gomez Perez‐Nievas, Wendy J. Noble
This study shows that BIN1 loss in Alzheimer's disease leads to tau mislocalization and altered synaptic structure and tau release.
Brain Communications · Jan 1, 2020Peer-reviewedNeuroscience