Author

Diane P. Hanger

King's College LondonORCID 0000-0002-3044-9816Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Wendy J. NobleiD· 3 shared Claire TroakesiD· 2 shared Deepak P. SrivastavaiD· 2 shared Despoina GoniotakiiD· 2 shared Richard KillickiD· 2 shared Anne CorbettiD· 1 shared Ariana P. GattiD· 1 shared Ayushin Ale· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersNeuroscience

Wendy J. NobleORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Proteomic Analysis Links Truncated Tau to Lysosome Motility, Autophagy and Endo-lysosomal Dysfunction

Despoina Goniotaki, Maximilian Hausherr, Steven Lynham, Ayushin Ale, George Chennell, Stefania Marcotti, Katrin Marcus, Wendy J. Noble, Diane P. Hanger, Graham Mathew Fraser, Deepak P. Srivastava

This study examines how Tau35 protein affects lysosomal function and autophagy, identifying early pathological changes linked to neurotoxicity in tauopathies.

Alzheimer s & Dementia · Dec 1, 2025Peer-reviewedNeuroscience

Overexpression of α-Synuclein Alters The Nanoscopic Organisation of Presynaptic Proteins

Iain A. Watson, Jéssika Cristina Bridi, Diane P. Hanger, Frank Hirth, Deepak P. Srivastava

This study shows that overexpressing α-synuclein variants alters presynaptic protein organisation without changing bouton structure, suggesting a disruption of presynaptic function through the MYCBP2-ELKS axis.

bioRxiv · Oct 10, 2025 · PreprintNeuroscience

Tau-mediated synaptic dysfunction is coupled with HCN channelopathy

Despoina Goniotaki, Francesco Tamagnini, Luca Biasetti, Svenja-Lotta Rumpf, Claire Troakes, Saskia J. Pollack, Shalom Ukwesa, Haoyue Sun, Igor Kraev, Louise C. Serpell, Wendy J. Noble, Kevin Staras, Diane P. Hanger

The paper shows that HCN channel dysfunction is linked to tauopathies, with altered synaptic structure and function in Alzheimer's and Tau35 mouse models.

Alzheimer s & Dementia · Jul 12, 2024Peer-reviewedNeuroscience

Loss of the Alzheimer’s-linked bridging integrator 1 (BIN1) protein affects synaptic structure and disrupts tau localisation and release

Elizabeth B. C. Glennon, Dawn H. W. Lau, Rebecca M. C. Gabriele, Matthew F Taylor, Claire Troakes, Sarah Opie-Martin, Christina Elliott, Richard Killick, Diane P. Hanger, Beatriz Gomez Perez‐Nievas, Wendy J. Noble

This study shows that BIN1 loss in Alzheimer's disease leads to tau mislocalization and altered synaptic structure and tau release.

Brain Communications · Jan 1, 2020Peer-reviewedNeuroscience

Identifying Novel Candidates for Re-Purposing as Potential Therapeutic Agents for Alzheimer’s disease

Clive G. Ballard, Byron Creese, Ariana P. Gatt, Patrick Doherty, Paul T. Francis, D Whitfield, Anne Corbett, J Corcoran, Diane P. Hanger, Sandrine Thuret, Richard Killick, Gareth Haydn Williams

The paper identifies 19 compounds from the CMAP library that show significant inverse correlation with Alzheimer's disease transcriptome signatures and pass in vitro screening assays.

bioRxiv · Apr 29, 2019 · PreprintNeuroscience