Richard Killick

The paper identifies cardiotonic steroids as potential repurposing candidates for lithium treatment of severe depression based on transcriptional and epidemiological analyses.

The paper shows that synaptotoxic forms of amyloid-beta and alpha-synuclein act through the same Wnt/PCP pathway to cause dendritic spine loss in neurodegenerative diseases.

The paper shows that Wnt-7a signaling from dendritic filopodia, combined with calcium signaling, is essential for synapse formation in cortical neurons.

This study shows fasudil reverses gene expression patterns associated with neurodegenerative disease in Alzheimer's model mice.

This paper demonstrates that multi-parametric manganese-enhanced MRI (MEMRI) can detect senile plaques in rodent AD models, showing manganese binds to plaques in 5xFAD mice but not TgF344-AD rats.

This study shows that BIN1 loss in Alzheimer's disease leads to tau mislocalization and altered synaptic structure and tau release.

The paper identifies 19 compounds from the CMAP library that show significant inverse correlation with Alzheimer's disease transcriptome signatures and pass in vitro screening assays.