Antigen-dependent inducible T cell reporter system for PET imaging of breast cancer and glioblastoma
Jaehoon Shin, Matthew F.L. Parker, Iowis Zhu, Aryn A. Alanizi, Carlos Iván Rodríguez, Raymond Liu, Payal B. Watchmaker, Mausam Kalita, Joseph E. Blecha, Justin M. Luu, Brian Wright, Suzanne E. Lapi, Robert R. Flavell, Hideho Okada, Thea Dorothy Tlsty, , David M. Wilson
This paper develops a PET imaging system using engineered T cells that report antigen recognition through inducible reporter gene expression, showing enhanced signal in antigen-expressing tumors.
Journal of Nuclear Medicine · Aug 18, 2022Peer-reviewedSynthetic Biology