Thea Dorothy Tlsty

The paper identifies a cold fibrotic network in LUSC TME driven by CAFs and shows its conservation in other CIACs, suggesting therapeutic targets.

The paper identifies a fibroblast state called STIF that drives YAP-dependent regenerative programs and (pre)malignancy through mechanotransduction in response to tissue injury.

This study identifies OPG-secreting CAFs as immunosuppressive stromal cells and shows that blocking OPG promotes immune infiltration and tumor regression in mouse models.

This study identifies immune cell changes and gene expression patterns in Barrett's esophagus progression to cancer using spatial and multi-omic analyses.

The paper identifies stromal protein profiles in breast cancer subtypes using proteomic analysis of FFPE tissues, revealing significant ECM and immune-related changes, particularly in metaplastic breast cancer.

This paper develops a PET imaging system using engineered T cells that report antigen recognition through inducible reporter gene expression, showing enhanced signal in antigen-expressing tumors.

This study identifies how changes in epithelial proportions and transcriptional states influenced by pregnancy and BMI affect hormone signaling and breast cancer risk in premenopausal women.