Iowis Zhu

This paper introduces Hybrid Receptors (Hybrid-Rs) to improve T cell therapy safety and programmability by combining CAR and SNIPR features for controlled gene regulation and reduced toxicity.

This study identifies interferon signaling as a key mediator of radiotherapy response in MPNSTs, linking it to T-cell recruitment and clinical outcomes.

This paper introduces SNIPR, a synthetic receptor that responds to soluble ligands, enabling targeted CAR T-cell therapy and synthetic cell signaling.

This paper develops a PET imaging system using engineered T cells that report antigen recognition through inducible reporter gene expression, showing enhanced signal in antigen-expressing tumors.

This paper designs and demonstrates synthetic receptors for tunable gene regulation in therapeutic cells, enabling customizable and clinical-ready gene control.