Stress-induced protein disaggregation in the Endoplasmic Reticulum catalysed by BiP
Eduardo P. Melo, Tasuku Konno, Ilaria Farace, Mosab Ali Awadelkareem, Lise R. Skov, Fernando Teodoro, Teresa P. Sancho, Adrienne W. Paton, James C. Paton, Matthew Fares, Pedro M. R. Paulo, Xin Zhang, Edward Avezov
The paper shows that ER stress activates a protein disaggregation system catalyzed by BiP, resolving aggregates in the ER using a novel live-cell monitoring method.
Nature Communications · May 6, 2022Peer-reviewedMolecular Biology