Edward Avezov

Mannosidases IA, IB and IC are in segregated vesicular structures and involved in both glycoprotein quality control and maturation

This study identifies that ManIA, ManIB, and ManIC localize to quality control vesicles and have distinct roles in glycoprotein maturation and ERAD, with different substrate preferences.

Tau aggregate replication occurs at the pre-synapse of cultured human neurons and increases with application of TNFa

The paper shows TNFα promotes tau aggregation at pre-synapses in human neurons, forming non-fibrillar aggregates that replicate rapidly.

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates

The paper shows that ER morphology affects neuronal bursting by controlling Ca2+ refill rates, linking ER structure to neuronal activity and neurodegeneration.

Brain cholesterol metabolites cause significant neurodegeneration in human iPSC-derived neurons

This study shows that 24S-HC and 27-HC, brain cholesterol metabolites, cause neuronal dysfunction in human iPSC-derived neurons by disrupting calcium signaling, organelle function, and alpha-synuclein accumulation.

Stress-induced protein disaggregation in the Endoplasmic Reticulum catalysed by BiP

The paper shows that ER stress activates a protein disaggregation system catalyzed by BiP, resolving aggregates in the ER using a novel live-cell monitoring method.