James C. Paton

The paper shows SubAB induces IFN-I in pDCs via STING activation and UPR, highlighting a novel mechanism of immune regulation.

The paper introduces a 9-digit code system for sialyltrisaccharides, revealing vast sialoglycan diversity and identifying a universal probe from AB5 toxin B subunits.

The paper shows that ER stress activates a protein disaggregation system catalyzed by BiP, resolving aggregates in the ER using a novel live-cell monitoring method.

The paper shows bacterial AB5 toxin B subunits evolve rapidly and independently of A subunits, with sialic acid binding preferences linked to host range and toxicity.

This study identifies factors causing FVIII aggregation in the ER and shows that chaperones and glucose metabolism regulate its solubility and secretion.

This study uses SMRT sequencing to compare the methylome of two STEC isolates, identifying differential methylation patterns linked to regulatory differences.

This paper shows that FICD's adenylyltransferase activity induces ER stress and that its disulfide-bond formation modulates its activity in the context of a hyperactive mutant.