The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer's Disease
Christina M. Moloney, Matthew H. Rutledge, Sydney A. Labuzan, Zhongwei Peng, Jessica F. Tranovich, Ashley C. Wood, Darren M. Rothberg, Ranjan Duara, Christian Lachner, Neill R. Graff‐Radford, Dennis W. Dickson, Nicholas M. Kanaan, Rickey E. Carter, Melissa Erin Murray
The paper develops a tangle maturity scale to evaluate Alzheimer's disease pathology using tau antibodies and machine learning, showing early tau modifications precede advanced ones.
bioRxiv · Jun 2, 2025 · PreprintNeuroscience