Author

Christina M. Moloney

Mayo ClinicORCID 0000-0002-4258-2294Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:machine learning (classical)· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:imaging· 1 Assay:protein structure· 1

Frequent Co-Authors

Dennis W. DicksoniD· 3 shared Melissa Erin MurrayiD· 3 shared Neill R. Graff‐RadfordiD· 3 shared Ranjan DuaraiD· 3 shared Sydney A. LabuzaniD· 3 shared Christian LachneriD· 2 shared Rickey E. CarteriD· 2 shared Ronald Carl PeterseniD· 2 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersNeuroscience

Dennis W. DicksonORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer's Disease

Christina M. Moloney, Matthew H. Rutledge, Sydney A. Labuzan, Zhongwei Peng, Jessica F. Tranovich, Ashley C. Wood, Darren M. Rothberg, Ranjan Duara, Christian Lachner, Neill R. Graff‐Radford, Dennis W. Dickson, Nicholas M. Kanaan, Rickey E. Carter, Melissa Erin Murray

The paper develops a tangle maturity scale to evaluate Alzheimer's disease pathology using tau antibodies and machine learning, showing early tau modifications precede advanced ones.

bioRxiv · Jun 2, 2025 · PreprintNeuroscience

Phosphorylated tau fluid biomarker sites recognize earlier neurofibrillary tangle maturity levels in the postmortem Alzheimer's disease brain

Christina M. Moloney, Sydney A. Labuzan, Julia E. Crook, Habeeba Siddiqui, Monica Castanedes‐Casey, Christian Lachner, Ronald Carl Petersen, Ranjan Duara, Neill R. Graff‐Radford, Dennis W. Dickson, Michelle M. Mielke, Melissa Erin Murray

The paper characterizes phosphorylated tau fluid biomarker sites in postmortem Alzheimer's disease brains, showing they correspond to earlier neurofibrillary tangle maturity levels.

Alzheimer s & Dementia · Aug 3, 2022Peer-reviewedNeuroscience

Leveraging selective hippocampal vulnerability among Alzheimer's disease subtypes reveals a novel tau binding partner SERPINA5

Angela M. Crist, Kelly M. Hinkle, Xue Wang, Christina M. Moloney, Billie J. Matchett, Sydney A. Labuzan, Isabelle Frankenhauser, Nkem O. Azu, Amanda M. Liesinger, Elizabeth R. Lesser, Daniel Serie, Zachary Quicksall, Tulsi Patel, Troy Carnwath, Michael A. Deture, , Melissa Erin Murray

The paper identifies SERPINA5 as a novel tau binding partner in Alzheimer's disease by analyzing hippocampal gene expression and neurofibrillary tangles.

bioRxiv · Dec 18, 2020 · PreprintNeuroscience