Author

Christian Lachner

Mayo ClinicORCID 0000-0002-1801-9768Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Dennis W. DicksoniD· 3 shared Melissa Erin MurrayiD· 3 shared Neill R. Graff‐RadfordiD· 3 shared Christina M. MoloneyiD· 2 shared Jessica F. Tranovich· 2 shared Ranjan DuaraiD· 2 shared Ronald Carl PeterseniD· 2 shared Sydney A. LabuzaniD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersNeuroscience

Dennis W. DicksonORCID

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3 papers

Recent·Most cited

Targeted proteomics of postmortem human brain reveals neurobiologic heterogeneity in Alzheimer's disease using NULISA technology

Sara Rose Dunlop, Sarah Lincoln, Zhongwei Peng, Neill R. Graff‐Radford, Christian Lachner, Gregory Scott Day, Jessica F. Tranovich, Robert Ross Reichard, Dennis W. Dickson, Ronald Carl Petersen, Bradley F. Boeve, Aivi Nguyen, Lea T. Grinberg, Jonathan Graff‐Radford, Alicia Algeciras‐Schimnich, Melissa Erin Murray

This study uses targeted proteomics to identify protein expression differences in Alzheimer's disease cases with varying clinical and neuropathological features.

bioRxiv · Jul 7, 2026 · PreprintNeuroscience

The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer's Disease

Christina M. Moloney, Matthew H. Rutledge, Sydney A. Labuzan, Zhongwei Peng, Jessica F. Tranovich, Ashley C. Wood, Darren M. Rothberg, Ranjan Duara, Christian Lachner, Neill R. Graff‐Radford, Dennis W. Dickson, Nicholas M. Kanaan, Rickey E. Carter, Melissa Erin Murray

The paper develops a tangle maturity scale to evaluate Alzheimer's disease pathology using tau antibodies and machine learning, showing early tau modifications precede advanced ones.

bioRxiv · Jun 2, 2025 · PreprintNeuroscience

Phosphorylated tau fluid biomarker sites recognize earlier neurofibrillary tangle maturity levels in the postmortem Alzheimer's disease brain

Christina M. Moloney, Sydney A. Labuzan, Julia E. Crook, Habeeba Siddiqui, Monica Castanedes‐Casey, Christian Lachner, Ronald Carl Petersen, Ranjan Duara, Neill R. Graff‐Radford, Dennis W. Dickson, Michelle M. Mielke, Melissa Erin Murray

The paper characterizes phosphorylated tau fluid biomarker sites in postmortem Alzheimer's disease brains, showing they correspond to earlier neurofibrillary tangle maturity levels.

Alzheimer s & Dementia · Aug 3, 2022Peer-reviewedNeuroscience