Differentiation of human T follicular helper cells in vitro requires co-operation between STAT3 and SMAD signaling cytokines that is restrained by IL-2
William S. Foster, Lucía Labeur-Iurman, Geoffrey S. Williams, Matthew J. Robinson, Gianluca Carlesso, Clare M. Lloyd, James A. Harker
This study shows that human T follicular helper cells differentiate in vitro through STAT3 and SMAD cytokine cooperation, but IL-2 inhibits this process.
bioRxiv · Jan 12, 2025 · PreprintImmunology